Congrong Wang,Cheng Hu,Rong Zhang,Yuqian Bao,Xiaojing Ma,Jingyi Lu,Wen Qin,Xinyu Shao,Junxi Lu,Jing Xu,Huijuan Lu,Kunsan Xiang,and Weiping Jia
Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People'e Hospital,shanghai diabetes institute,shanghai clinical center faor diabetes
Objective:Hepatocyte nuclear factor 1*(HNF1B) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis.Previous studies have reported thar common variants of HNF1B were associated with type 2 diabetes in caucasians and west africans.However analysis in the subjecs from the botnia study and malm?Preventive project produced a conflicting result and the role for HNF1B in type 2 diabetes susceptibility has remained unclear.We therefore investigated common variants across the HNF1B gene in a chinese population.
Research Design and Methods:Fifteen tagging SNPs were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n=1,859) and normal glucose regulation (n=1,785).
Results:Consistent with the initial study,we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds rario [OR] 1.16 [95 CI% 1.05 - 1.29],P=0.0035,empirical p=0.0475).
Furthermore,the at-risk G allele was associated with earlier age an diagnosis in the type 2 diabetic subjects(P=0.0228).
Conclusions:The result of this study provides evidence that variants in the HNF1B region contribute to susceptibility to type 2 diabetes in the Chinese population.
Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People'e Hospital,shanghai diabetes institute,shanghai clinical center faor diabetes
Objective:Hepatocyte nuclear factor 1*(HNF1B) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis.Previous studies have reported thar common variants of HNF1B were associated with type 2 diabetes in caucasians and west africans.However analysis in the subjecs from the botnia study and malm?Preventive project produced a conflicting result and the role for HNF1B in type 2 diabetes susceptibility has remained unclear.We therefore investigated common variants across the HNF1B gene in a chinese population.
Research Design and Methods:Fifteen tagging SNPs were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n=1,859) and normal glucose regulation (n=1,785).
Results:Consistent with the initial study,we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds rario [OR] 1.16 [95 CI% 1.05 - 1.29],P=0.0035,empirical p=0.0475).
Furthermore,the at-risk G allele was associated with earlier age an diagnosis in the type 2 diabetic subjects(P=0.0228).
Conclusions:The result of this study provides evidence that variants in the HNF1B region contribute to susceptibility to type 2 diabetes in the Chinese population.
No comments:
Post a Comment