Obese adipose tissue is characterized by infiltration of macrophages.We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue.This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-associated insulin resistance.Here,we used a conditional cell ablation system,based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter,to study the effects of depletion of CD11c+ cells in obese mouse models.Our results show that CD11c+ cell depletion results in rapid normalization of insulin sensitivity.Futhermore,CD11c+ cell ablation leads to a marked decrease in inflammatory markers,both lacally and systemically,as reflected by gene expression and protein levels.Together,these results indicate that these CD11c+ cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type II diabetes.
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